CABATINA® Injectable solution


antihemorrhagic

CABATINA® INJECTABLE is indicated for the initial emergency treatment of acute and over-acute poisonings generated by anticoagulant rodenticides.

Technical Specification

Species


Dogs.

Dosage form


Injectable solution

Therapeutic action


antihemorrhagic

Composition


Each 1 mL of solution for injection contains:
Phytomenadione.......................10 mg
Excipients q.s.p........................ 1 mL

Properties


Vitamin K is a cofactor in the last stage of hepatic synthesis of coagulation factors II (prothrombin), VII (proconvertin), IX (plasma thromboplastin component) and X (Stuart factor).

In veterinary medicine, the most frequent cause of the cessation of K-dependent coagulation factor formation is intoxication by anticoagulant rodenticides.

Phytomenadione (Vitamin K1) antagonizes the effects of anticoagulant rodenticidal agents and makes it possible to reactivate the production process of K-dependent coagulation factors.

Indications


CABATINA® INJECTABLE is indicated for the initial emergency treatment of acute and over-acute poisonings generated by anticoagulant rodenticides.

Route od administration and dosage


Route of administration: Subcutaneous.

Dose:

  • Initial emergency treatment:

Administer 2.5 to 5 mL of CABATINA® INJECTABLE product for every 10 kg of body weight (equivalent to 2.5 - 5 mg / kg of body weight of Phytomenadione, respectively), in a single dose.

According to the evolution of the clinical picture, type of rodenticide responsible for the intoxication and at the discretion of the treating Veterinarian, continue the treatment with another veterinary drug based on Phytomenadione administered orally.

  • Cases that require continuing with injectable treatment:

In those cases that after the emergency dose, it is not possible to establish an oral therapy, treatment with the CABATINA® INJECTABLE product can be continued, in doses of 2.5 mL of product per 10 Kg of weight. body weight (equivalent to 2.5 mg / Kg of body weight of Phytomenadione), every 12 hours, with a maximum of 4 total administrations.

The duration of the injectable treatment (between 1 to 4 administrations) will depend on the type of rodenticide responsible for the poisoning, the evolution of the clinical picture and the criteria of the treating Veterinarian. Subsequently, treatment with another veterinary drug based on Phytomenadione can be continued orally.

How to use:
Administer the dose of the product at several injection sites to accelerate its absorption and using the smallest gauge possible to minimize the risk of bleeding.

Drug interactions


The following medications can prolong or potentiate the effects of anticoagulants and antagonize some of the therapeutic actions of Phytomenadione (vitamin K1): Phenylbutazone, Acetylsalicylic acid, Chloramphenicol, Sulfonamides (including sulfa / trimethoprim), Diazoxide, Allopurinol, Cimetidine, Metronidazole, Anabolic steroids, Erythromycin, Ketoconazole, Propanolol and thyroid drugs, therefore it is not recommended to use concomitantly with other pharmaceuticals.


Contraindications


  • Do not administer in animals with known hypersensitivity to Phytomenadione (Vitamin K1).
  • Do not administer in patients with severe liver failure.
  • Do not administer intravenously due to the risk of anaphylactic reactions.
  • Do not administer intramuscularly due to the risk of bleeding and bruising.
  • Do not administer the product for more than 4 administrations due to the risk of producing hemolysis.

Precautions


Special warnings and precautions for use:

  • Therapy with CABATIN® INJECTABLE administered subcutaneously should be continued by the oral administration of Phytomenadione (vitamin K1).
  • In animals with vomiting, anorexia or in acute / over-acute conditions, in which Phytomenadione (vitamin K1) cannot be administered orally, subcutaneous administration is recommended, however, subcutaneous administration should be replaced by the oral route. , as soon as possible.
  • Subcutaneous injections can be poorly absorbed in hypovolemic animals.
  • Phytomenadione (vitamin K1) does not correct hypoprothrombinemia resulting from hepatocellular damage.
  • In an emergency due to lack of clotting factors, blood transfusions or blood products should be administered, since it takes approximately 6 to 12 hours from the administration of Phytomenadione (vitamin K1) for new clotting factors to form.
  • Keep out of the reach of children.

Special precautions for use


Use during pregnancy, lactation and in breeding animals

Exogenous Phytomenadione (vitamin K1) enters the milk and crosses the placental barrier. There is no formal research on the safety of Phytomenadione during pregnancy, therefore, use it only according to the benefit / risk assessment made by the treating Veterinarian.

Special precautions for the operator


  • In the case of ocular exposure, the eyes should be flushed with copious amounts of water at room temperature for at least 15 minutes. If irritation, pain, inflammation, tearing or photophobia persist, the patient should be evaluated by a doctor.
  • In the case of dermal exposure, contaminated clothing should be removed and the exposed area washed thoroughly with soap and water. If there is irritation or pain the patient should be evaluated by a doctor.
  • In the case of accidental injection, medical attention should be sought.

Warnings


Keep out of the reach of children.

Adverse effects


Unwanted effects and adverse reactions:

High doses of Phytomenadione (vitamin K1) should be administered with caution due to the fact that Heinz body anemia has been reported in dogs that received doses of 4 mg / kg for 5 days.
In some dogs, cases of urticaria and abscess formation have been reported after subcutaneous administration of Phytomenadione (vitamin K1)

Observations


Special precautions for disposal of unused product or waste material:
Dispose of unused product remains in its original container, well closed. Dispose of the waste of this product with care together with household waste.

Conservation


  • Keep the product, closed or once opened, at a temperature between 2 ° C and 30 ° C, protected from light.
  • Once opened, use the product within 2 weeks.
  • Discard the unused product after that period of time.

Condition of sale


Sale with Veterinary Medical prescription.

Presentation


20 mL vial

Prepared by


Laboratorio Drag Pharma Chile Invetec S.A. 

Records


Chile: Reg. SAG N° 2329 

Countries where it is marketed


Imported and distributed in Bolivia by:

ZOOFARMA
TEL: +(591)222-3357
Street Díaz Romero 1339, La Paz.

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Drag Pharma Lab is not responsible for the consequences of misuse of the products, and the use of this information without consulting a veterinarian