COLIMIC® Injectable solution
Spasmolytic.
Antispasmodic, relaxant of the smooth muscles in states of gastrointestinal colic and as an adjunct in diarrhea and vomiting.
Technical Specification
Species
Cattle, horses, pigs and sheep.
Dosage form
Injectable solution.
Therapeutic action
Spasmolytic.
Composition
Each 10 mL of solution contains:
Papaverine Hydrochloride ............ 300 mg
(Equivalent to 271 mg of Papaverine)
Atropine Sulfate ....................... 30 mg
(Equivalent to 26 mg of Atropine)
Excipients q.s.p ....................... 10 mL
Indications
Antispasmodic, relaxant of the smooth muscles in states of gastrointestinal colic and as an adjunct in diarrhea and vomiting.
Route od administration and dosage
Administration routes:
Intramuscular or subcutaneous administration
Active ingredients dose:
Atropine:
- Bovine and horses: 0.03 – 0.06 mg/Kg
- Pigs: 0.1 mg/Kg
- Ovine: 0.03-0.3 mg/Kg
Papaverine:
- Bovine and horses: 0.3-0.54 mg/Kg
- Pigs: 0.11 mg/Kg
- Ovine: 0.3 – 3.3 mg/Kg
Product dose:
- Bovine and horses: 1-2 mL/100 Kg of weight, in a single dose.
- Pigs: 4 mL / 100 Kg of weight, in a single dose.
- Ovine: 1-12 mL/100 Kg of weight, in a single dose.
Drug interactions
- The following actives can increase the activity or toxicity of Atropine and its derivatives: Amantadine, other anticholinergic agents, anticholinergic muscle relaxants, antihistamines (eg Diphenhydramine), Disopyramide, Meperidine, Phenothiaripzines, Procainamide, Primidone, Tricyclic antidepressants (eg Amiticiline antidepressants (eg Amiticiline antidepressants) , Clomipramine).
- The use of Atropine with alpha-2 agonists (eg Dexmedetomidine, Medetomidine) can significantly increase blood pressure, heart rate and the incidence of arrhythmias.
- Atropine can aggravate some symptoms caused by Amitraz intoxication; leading to hypertension and increased inhibition of peristalsis.
- Long-term use of Atropine in conjunction with corticosteroids can increase intraocular pressure.
- Atropine and its derivatives can antagonize the actions of metoclopramide.
Contraindications
- Do not administer in animals with glaucoma and heart failure.
- Do not administer in cases of intestinal obstruction.
- Do not administer in animals with known hypersensitivity to Atropine or Papaverine.
- Do not administer during pregnancy or while breastfeeding.
Special precautions for use
- Anticholinergic agents should be administered with caution in geriatric animals, with kidney and liver disease or those with esophageal reflux.
- Administer with caution in horses as it can induce colic.
Warnings
Keep out of reach of children.
Adverse effects
Mydriasis, dry mucous membranes and intestinal atony in variable degrees. The most frequently described adverse effects are ruminal bloating in ruminants and tachycardia in horses.
Guard period
Meat and milk: 0 days.
Observations
Special precautions for disposal of unused product or waste material:
Dispose of this product waste carefully with household waste. Do not dispose of containers with product remains on the ground or water courses. For expired or unused products, contact the manufacturing laboratory.
Conservation
Store between 15 and 30 °C, protected from light.
Once the container is opened, use within 28 days. Discard unused product after that
time frame.
Condition of sale
To be supply only on veterinary prescription.
Presentation
10 mL and 50 mL vial
Prepared by
Drag Pharma Laboratory.
Records
Reg. SAG No. 928
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